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TRANSFORMATION OF 4-SUBSTITUTED TETRAHYDROPYRROLOBENZODIAZEPINES IN A THREE-COMPONENT REACTION WITH METHYL PROPIOLATE AND INDOLE

Л. Г. Воскресенский, Т. Н. Борисова, М. И. Бабаханова, А. А. Титов, Т. М. Червякова, Р. А. Новиков, А. В. Бутин, В. Н. Хрусталев, А. В. Варламов
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Abstract


The three-component reaction of 4-phenyl-, p-methoxyphenyl-, and thienylpyrrolo[1,2-a][1,4]benzodiazepines with methyl propiolate and indole in dichloromethane proceeds through opening of the diazepine ring. The major transformation products isolated are substituted pyrroles, namely, 1‑(2‑aminomethylphenyl)-5-(arylmethyl)-2-(indol-1(3)-yl)pyrroles and 1-(2-aminomethylphenyl)-2-aryl-(indol-3‑yl)-methylpyrroles.

How to Cite
Voskressensky, L. G.; Borisova, T. N.; Babakhanova, M. I.; Titov, A. A.; Chervyakova, T. M.; Novikov, R. A.; Butin, A. V.; Khrustalev, V. N.; Varlamov, A. V. Chem. Heterocycl. Compd. 2014, 49, 1785. [Khim. Geterotsikl. Soedin. 2013, 1925.]

For this article in the English edition see DOI 10.1007/s10593-014-1431-5


Keywords


pyrrolylindoles; tetrahydropyrrolo[1,2-a][1,4]benzodiazepines; domino reactions; multi-component reaction; opening of the diazepine ring

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