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PREPARATION OF 6-UNSUBSTITUTED 3,4-DIHYDROPIRIMIDIN-2(1Н)-ONES AND 2-ARYLAMINOPYRIMIDINES

С. Терентьева, Д. Муцениеце, В. Лусис
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Abstract


A series of new 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones have been obtained from methyl propiolate, as well as from methyl 3-diethylaminoacrylate, using the Biginelli reaction. By subsequent oxidation of the pyrimidine reing, clorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine they have been converted into heretofore unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids also were obtained.

How to Cite
Terentjeva, S.; Muceniece, D.; Lusis, V. Chem. Heterocycl. Compd. 2014, 49, 1757. [Khim. Geterotsikl. Soedin. 2013, 1896.]

For this article in the English edition see DOI 10.1007/s10593-014-1428-0


Keywords


2-oxo-1,2,3,4-tetrahydropyrimidines; 2-oxo-1,2-dihydropyrimidines; 2-chloropyrimidines; 2-(arylamino)pyrimidines; Biginelli reaction

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