ACTIVATION OF NUCLEOPHILIC SUBSTITUTION REACTIONS IN 4-NITROQUINOLINE N-OXIDE BY v-ACCEPTORS

Abstract

The method of HPLC was used to investigate the influence of temperature, solvent, the nature of the nucleophile, and the type of v-acceptor on the rate of substitution of the nitro group in 4-nitroquinoline N-oxide by atoms of halogens. Convenient methods for the synthesis of 4-halo-substituted quinoline N-oxides under conditions of activation of the reaction by Lewis and Bronsted–Lowry acids are proposed.

Authors: V. P. Andreev and A. V. Ryzhakov.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (11), pp 1329-1333

http://link.springer.com/article/10.1007/BF02252003