7-DIALKYLAMINOMETHYL-2,4,5-TRIMETYL- AND 2,4,5-TRIMETHYL-7-PHENYLIMINOMETHYL-1,2,3,4-TETRAHYDROPYRROLO[1,2-<i>c</i>]PYRIMIDINES

Abstract

The Mannich aminoalkylation of 2,4,5-trimethyl-1,2,3,4-tetrahydropyrrolo[1,2-c]pyrimidine and condensation of its 7-formyl derivative with aniline have been studied. 7-Morpholinomethyl- and 7-(N-methylpiperazinylmethyl)-substituted derivatives have been isolated. 7-Dimethylaminomethyl- and 7-phenyliminomethyl-substituted derivatives of tetrahydropyrrolo[1,2-c]pyrimidines are easily cleaved in the process of chromatographic isolation.

Authors: A. V. Varlamov, T. N. Borisova, E. A. Sorokina, A. I. Chernyshev, and A. N. Levov.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (12), pp 1455-1458

http://link.springer.com/article/10.1007/BF02251822