PRODUCTS OF THE REACTION OF 2-CHLORO-6-THIO-7-METHYLPURINE WITH AMINES

Authors

  • П. М. Кочергин Center for the Chemistry of Medicinal Compounds, All Russian Chemico-Pharmaceutical Science Research Institute, Moscow
  • E. В. Александрова Zaporozh'ye State Medicinal University
  • В. С. Корсyнский Center for the Chemistry of Medicinal Compounds, All Russian Chemico-Pharmaceutical Science Research Institute, Moscow

DOI:

https://doi.org/10.1007/112

Keywords:

chloropurine, thiopurines, chlorothiopurines, aminopurines, aniline, morpholine, piperidine

Abstract

Treatment of 2-chloro-6-thio-7-methylpurine with aniline, piperidine, or morpholine with heating in DMF gives 2-phenylamino(piperidino or morpholino)-6-thio-7-methylpurine. The scheme for the formation of the side products 2,6-dithio- and 2,6-dipiperidino-7-methylpurine is discussed.

Authors: P. M. Kochergin, E. V. Aleksandrova, and V. S. Korsunskii.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (1), pp 74-76

http://link.springer.com/article/10.1007/BF02256849

Published

2012-09-28

Issue

No. 1 (2000)

Section

Original Papers