

2,1-BENZOTHIAZINE 2,2-DIOXIDES. 3. 4-HYDROXY-1-METHYL-2,2-DIOXO-N-(1,3-THIAZOL-2-YL)-1Н-2λ6,1-BENZOTHIAZINE-3-CARBOXAMIDES – A NEW GROUP OF POTENTIAL ANALGETICS

Abstract
We have developed an effective synthetic method and prepared several 4-hydroxy-1-methyl-2,2-dioxo-N‑(1,3-thiazol-2-yl)-1Н-2λ6,1-benzothiazine-3-carboxamides and a few structurally related heterocyclic arylamides. The structural features of one of the substituted thiazolyl-2-amides obtained have been investigated. Compounds with a high analgesic activity have been identified within this group by pharmacological screening.
How to Cite
Ukrainets, I. V.; Petrushova, L. A.; Dzyubenko, S. P.; Sim, G. Chem. Heterocycl. Compd. 2014, 50, 103. [Khim. Geterotsikl. Soedin. 2014, 114.]
For this article in the English edition see DOI 10.1007/s10593-014-1452-0
Keywords
amides; 2-aminothiazoles; 2,1-benzothiazines; esters; analgesic activity
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv