2,1-BENZOTHIAZINE 2,2-DIOXIDES. 3. 4-HYDROXY-1-METHYL-2,2-DIOXO-<i>N</i>-(1,3-THIAZOL-2-YL)-1<i>Н</i>-2λ6,1-BENZOTHIAZINE-3-CARBOXAMIDES – A NEW GROUP OF POTENTIAL ANALGETICS

Authors

  • И. В. Украинец National University of Pharmacy
  • Л. А. Петрушова National University of Pharmacy
  • С. П. Дзюбенко Vinnitsya National Pirogov Memorial Medical University
  • Г. Сим Far-Eastern State Medical University

DOI:

https://doi.org/10.1007/1154

Keywords:

amides, 2-aminothiazoles, 2, 1-benzothiazines, esters, analgesic activity

Abstract

We have developed an effective synthetic method and prepared several 4-hydroxy-1-methyl-2,2-dioxo-N‑(1,3-thiazol-2-yl)-1Н-2λ6,1-benzothiazine-3-carboxamides and a few structurally related heterocyclic arylamides. The structural features of one of the substituted thiazolyl-2-amides obtained have been investigated. Compounds with a high analgesic activity have been identified within this group by pharmacological screening.

How to Cite
Ukrainets, I. V.; Petrushova, L. A.; Dzyubenko, S. P.; Sim, G. Chem. Heterocycl. Compd. 2014, 50, 103. [Khim. Geterotsikl. Soedin. 2014, 114.]

For this article in the English edition see DOI 10.1007/s10593-014-1452-0

Author Biography

И. В. Украинец, National University of Pharmacy

Игорь Васильевич Украинец

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Published

2014-02-10

Issue

No. 1 (2014)

Section

Original Papers