SYNTHESIS OF <i>tert</i>-BUTYL 1-(5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-<i>a</i>]PYRAZIN-3-YL)ETHYLCARBAMATE

Authors

  • Y. Liu Shandong Polytechnic University
  • X. Liu Qilu Hospital, Shandong University
  • W. Sun School of Pharmaceutical Sciences, Shandong University
  • H. Fang School of Pharmaceutical Sciences, Shandong University
  • M. Li School of Pharmaceutical Sciences, Shandong University
  • W. Xu School of Pharmaceutical Sciences, Shandong University

DOI:

https://doi.org/10.1007/1176

Keywords:

tert-butyl 1-(5, 8-dioxo-5, 6, 7, 8-tetrahydro[1, 3]thiazolo[3, 4-a]pyrazin-3-yl)-ethylcarbamate, X-ray crystal structure

Abstract

Two diastereomers of previously unknown diketopiperazines tert-butyl 1-(5,8-dioxohexahydro[1,3]thiazolo[3,4-a]pyrazin-3-yl)ethylcarbamate were synthesized and separated by column chromatography on silica gel. During the cultivation of the crystal of one of compounds, the product was oxidized to respective tert-butyl 1-(5,8-dioxo-5,6,7,8-tetrahydro[1,3]thiazolo[3,4-a]pyrazin-3-yl)ethylcarbamate. The X-ray crystal structure of the latter was established.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (6), pp 950-954

http://link.springer.com/article/10.1007/s10593-012-1082-3

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Published

2013-11-15

Issue

No. 6 (2012)

Section

Original Papers