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SYNTHESIS OF 3-SUBSTITUTED 2-AMINO-1-HYDROXY-1H-INDOLE-5,6-DICARBONITRILES

С. И. Филимонов, Ж. В. Чиркова, В. С. Шарунов, И. Г. Абрамов, Г. А. Сташина, С. И. Фирганг, К. Ю. Супоницкий
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Abstract


A method of synthesizing new 3-substituted 2-amino-1-hydroxy-1H-indole-5,6-dicarbonitriles has been developed based on the reductive cyclization of substituted 4-cyanomethyl-5-nitrophthalonitriles.

Authors: S. I. Filimonov, Zh. V. Chirkova, V. S. Sharunov, I. G. Abramov, G. A. Stashina, S. I. Firgang, and K. Yu. Suponitsky.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (3), pp 427-435

http://link.springer.com/article/10.1007/s10593-012-1010-6


Keywords


2,1-benzisoxazoles; 1-hydroxy-1H-indole-5,6-dicarbonitriles; phthalonitriles; C-nucleophilic substitution; reductive cyclization

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