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SYNTHESIS OF PYRROLO[2,3-d]PYRIMIDINES WITH 3-AMINO-2-HYDROXYPROPYL SUBSTITUENTS

Л. В. Музычка, Е. В. Вервес, И. О. Яремчук, О. Б. Смолий
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Abstract


A novel route has been found for the synthesis of pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines. They are promising reagents for the preparation of pyrrolo[2,3-d]pyrimidine-6-carboxylic acid amides which contain a 3-amino-2-hydroxypropyl substituent in position 7 of the heterocyclic ring.

Authors: L. V. Muzychka, E. V. Verves, I. O. Yaremchuk, and O. B. Smolii.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (3), pp 481-487

http://link.springer.com/article/10.1007/s10593-012-1019-x


Keywords


pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines; pyrrolo[2,3-d]pyrimidines; bromolactonization

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