SYNTHESIS AND ANTITUMOR ACTIVITY OF 3-[(METHYL)BIS(5-TRIALKYLSILYLFURAN-2-YL)SILYL]PROPYLAMINES

Authors

  • Л. Игнатович Latvian Institute of Organic Synthesis
  • В. Романов Latvian Institute of Organic Synthesis
  • Я. Спура Latvian Institute of Organic Synthesis
  • Ю. Попелис Latvian Institute of Organic Synthesis
  • И. Домрачева Latvian Institute of Organic Synthesis
  • И. Шестакова Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/1319

Keywords:

3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines, cytotoxicity, hydrosilylation

Abstract

Novel 3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and the alkyl substituent at the silicon atom on the cytotoxicity of the compounds have been studied.

Authors: L. Ignatovich, V. Romanov, J. Spura, J. Popelis, I. Domracheva, and I. Shestakova.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (12), pp 1502-1508

http://link.springer.com/article/10.1007/s10593-012-0940-3

Published

2013-12-06

Issue

Section

Original Papers