SYNTHESIS OF 6-SULFAMOYLSACCHARIN AND STUDY OF ITS REACTIVITY IN ALKYLATION REACTIONS

Authors

  • Е. М. Иванова Latvian Institute of Organic Synthesis
  • Э. Ю. Симин Latvian Institute of Organic Synthesis
  • И. В. Возный Latvian Institute of Organic Synthesis
  • П. Трапенциерис Latvian Institute of Organic Synthesis
  • Р. Жалубовскис Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/1329

Keywords:

6-sulfamoylsaccharin, alkylation, benzylation, oxidative cyclization, regioselectivity

Abstract

An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzo-thiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occurs regioselectively at the isothiazoline ring nitrogen atom.

Authors: E. M. Ivanova, E. Yu. Simin, I. V. Vozny, P. Trapencieris, and R. Žalubovskis.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (12), pp 1561-1564

http://link.springer.com/article/10.1007/s10593-012-0948-8

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Published

2013-12-09

Issue

No. 12 (2011)

Section

Original Papers