2,1-BENZOTHIAZINE-2,2-DIOXIDES. 4. SYNTHESIS, STRUCTURE, AND ANALGESIC PROPERTIES OF 4-HYDROXY-1-METHYL-N-(PYRIDIN-2-YL)-2,2-DIOXO-1H-26,1-BENZOTHIAZINE-3-CARBOXAMIDES

Abstract

An improved method for the reaction of methyl-4-hydroxy-1-methyl-2,2-dioxo-1Н-2λ⁶,1-benzothiazine-3-carboxylate with hetaryl amines, which allows to obtain 4-hydroxy-1-methyl-2,2‑dioxo-N-(pyridin-2-yl)-1Н-2λ⁶,1-benzothiazine-3-carboxamides in good yields and with high purity. It was shown by x-ray analysis that the synthesized compounds exist in the zwitter-ion form. The mass spectra indicate their propensity to SO₂ extrusion. In the pharmacological tests, rpomising compounds were found with analgesic activities exceeding those of known oxicam type drugs.

How to Cite
Ukrainets, I. V.; Petrushova, L. A.; Dzyubenko, S. P.; Liu Yangyang Chem. Heterocycl. Compd. 2014, 50, 564. [Khim. Geterotsikl. Soedin. 2014, 614.]

For this article in the English edition see DOI 10.1007/s10593-014-1508-1