NEW METHOD FOR THE SYNTHESIS OF 4,5-DIHYDRO-1,4-BENZOTHIAZEPIN-3(2<i>H</i>)-ONES DERIVATIVES
DOI:
https://doi.org/10.1007/1449Keywords:
4, 5-dihydro-1, 4-benzothiazepin-3(2H)-one 1, 1-dioxides, 4-benzothiazepin-3(2H)-ones, acylation, intramolecular nucleophilic substitutionAbstract
A new method has been developed for the synthesis of 4,5-dihydro-1,4-benzothazepin-3(2H)ones derivatives by the acylation of N-substituted 2-chloro-5-nitrobenzylamines with acetylmercaptoacetyl chloride and α-acetylmercaptopropionyl chloride with subsequent removal of the S-acetyl protecting group and intramolecular nucleophilic substitution. The oxidation of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones to the corresponding 1,1-dioxides has been investigated.
Authors: T. A. Volovnenko, T. N. Tarasiuk, Yu. M. Volovenko, and T. M. Tkachuk
English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (8), pp 1043-1047
http://link.springer.com/article/10.1007/s10593-011-0872-3
