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AT THE CROSSROADS OF HETEROCYCLIC AND PEPTIDE CHEMISTRIES. THE AMINOACYL INCORPORATION REACTION IN THE SYNTHESIS OF MEDIUM-SIZED RING HETEROCYCLES

V. N. Azev, A. N. Chulin, I. L. Rodionov
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Abstract


Aminoacyl incorporation reaction of peptides is considered in the context of synthetic heterocyclic chemistry with the particular emphasis on scope, mechanism and major by-products of the reaction. Medium-sized mono and bicyclic molecules available via aminoacyl incorporation reaction are unique building blocks with significant promise in biomolecular design.

How to Cite
Azev, V. N.; Chulin, A. N.; Rodionov, I. L. Chem. Heterocycl. Compd. 2014, 50, 145. [Khim. Geterotsikl. Soedin. 2014, 166.]

For this article in the English edition see DOI 10.1007/s10593-014-1457-8


Keywords


aminoacyl lactams; cyclol; dioxodiazacycloalkanes; trioxotriazacycloalkanes; aminoacyl incorporation; medium-sized ring; synthetic backbone scaffold

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