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4-AMINO-2-ARYL-3-CYANO-1,2-DIHYDROPYRIMIDO[1,2-a]BENZIMIDAZOLES AND THEIR PYRIMIDINE ANALOGS AS NEW ANTICANCER AGENTS

V. A. Risley, S. Henry, M. V. Kosyrikhina, M. R. Manzanares, I. Payan, C. D. Downer, C. C. Hellmann, S. Van Slambrouck, L. V. Frolova
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Abstract


A multicomponent condensation between 2-aminobenzimidazole, malononitrile, and an aryl or heteroaryl aldehyde was used for the synthesis of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles. In addition, a new method of synthesis of corresponding pyrimido[2,1-a]benzimidazole derivatives was developed. These syntheses were used to prepare a library of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles and their corresponding pyrimido[2,1-a]benzimidazole derivatives. This library of compounds was then tested against pancreatic and breast cancer cell lines. A number of compounds were found to possess notable anticancer activity.

How to Cite
Risley, V. A.; Henry, S.; Kosyrikhina, M. V.; Manzanares, M. R.; Payan, I.; Downer, C. D.; Hellmann, C. C.; Van Slambrouck, S.; Frolova, L. V. Chem. Heterocycl. Compd. 2014, 50, 185. [Khim. Geterotsikl. Soedin. 2014, 209.]

For this article in the English edition see DOI 10.1007/s10593-014-1460-0


Keywords


benzimidazole; 1,2-dihydropyrimidine; 1,2-dihydropyrimido[1,2-a]benzimidazoles; pyrimidine; pyrimido[2,1-a]benzimidazoles; anticancer activity; multicomponent reactions

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