4-AMINO-2-ARYL-3-CYANO-1,2-DIHYDROPYRIMIDO[1,2-<i>a</i>]BENZIMIDAZOLES AND THEIR PYRIMIDINE ANALOGS AS NEW ANTICANCER AGENTS
DOI:
https://doi.org/10.1007/1469Keywords:
benzimidazole, 1, 2-dihydropyrimidine, 2-dihydropyrimido[1, 2-a]benzimidazoles, pyrimidine, pyrimido[2, 1-a]benzimidazoles, anticancer activity, multicomponent reactionsAbstract
A multicomponent condensation between 2-aminobenzimidazole, malononitrile, and an aryl or heteroaryl aldehyde was used for the synthesis of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles. In addition, a new method of synthesis of corresponding pyrimido[2,1-a]benzimidazole derivatives was developed. These syntheses were used to prepare a library of 4-amino-2-aryl-3-cyano-1,2-dihydropyrimido[1,2-a]benzimidazoles and their corresponding pyrimido[2,1-a]benzimidazole derivatives. This library of compounds was then tested against pancreatic and breast cancer cell lines. A number of compounds were found to possess notable anticancer activity.
How to Cite
Risley, V. A.; Henry, S.; Kosyrikhina, M. V.; Manzanares, M. R.; Payan, I.; Downer, C. D.; Hellmann, C. C.; Van Slambrouck, S.; Frolova, L. V. Chem. Heterocycl. Compd. 2014, 50, 185. [Khim. Geterotsikl. Soedin. 2014, 209.]
For this article in the English edition see DOI 10.1007/s10593-014-1460-0
