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THREE-COMPONENT CONDENSATION OF 2,5-DIALKYLPHENOLS, ISOBUTYRIC ALDEHYDE, AND NITRILES. SYNTHESIS OF NOVEL 2-AZASPIRO[4.5]DECA-6,9-DIEN- AND 2-AZASPIRO[4.5]DECA-1,6,9-TRIEN-8-ONES

Ю. С. Рожкова, К. А. Галата, Т. С. Вшивкова, Ю. В. Шкляев
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Abstract


Interaction of 2,5-dialkylphenols (2,5-dimethylphenol and 2-isopropyl-5-methylphenol) with isobutyric aldehyde and nitriles catalyzed by concentrated sulfuric acid leads to the formation of 1-R-9-alkyl-3,3,6-trimethyl-2-azaspiro[4.5]deca-6,9-dien-8-ones and 1-R-9-alkyl-3,3,6-trimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones.

How to Cite
Rozhkova, Yu. S.; Galata, K. A.; Vshivkova, T. S.; Shklyaev, Yu. V. Chem. Heterocycl. Compd. 2014, 50, 204. [Khim. Geterotsikl. Soedin. 2014, 228.]

For this article in the English edition see DOI 10.1007/s10593-014-1462-y


Keywords


2-azaspiro[4.5]deca-6,9-dien-8-ones; 2-azaspiro[4.5]deca-1,6,9-trien-8-ones; 2-isopropyl-5-methylphenol; 2,5-dimethylphenol; isobutyric aldehyde; nitrile; sulfuric acid; multicomponent reactions

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