4-HYDROXY-2-QUINOLONES. 199. USE OF <i>N,N</i>'-DICYCLOHEXYLCARBODIIMIDE IN THE SYNTHESIS OF ETHYL 4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATES

Abstract

A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3‑carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.

Authors: I. V. Ukrainets, N. Yu. Golik, O. V. Bevz, and O. V. Gorokhova

English Translation in Chemistry of Heterocyclic Compounds, 2011, 47 (7), pp 833-837

http://link.springer.com/article/10.1007/s10593-011-0843-8