SYNTHESIS OF 2-QUINOLINECARBOXAMIDE DERIVATIVES AS POTENTIAL HDAC INHIBITORS

Authors

  • O. Habarova
  • O. Bobiļeva
  • E. Loža
  • N. Romančikova

DOI:

https://doi.org/10.1007/1527

Keywords:

inhibitors of histone deacetylase, quinoline, Zn2 chelating groups

Abstract

Inhibition of histone deacetylase activity appears as an original and effective approach for the treatment of cancer. A series of novel quinoline-containing derivatives has been synthesized and found that some of these compounds possess nanomolar histone deacetylase inhibitory activity.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 719-727

http://link.springer.com/article/10.1007/s10593-011-0825-x

Published

2014-01-23

Issue

Section

Original Papers