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SYNTHESIS OF (PYRIDIN-2-YL)HYDRAZONE RHENIUM(I) TRICARBONYL COMPLEXES THAT EXHIBIT pH SENSITIVE FLUORESCENCE

S. Hapuarachchige, B. K. Bryant, J. B. Arterburn
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Abstract


There is great potential for novel diagnostic and therapeutic agents that combine multiple imaging modalities. The combination of optical and radionuclide imaging systems is particularly promising for the improved management of cancer. We describe a new heteroorganometallacyclic system containing the (2-pyridyl)hydrazono-Re(CO)3 that exhibits pH sensitive photophysical properties. This optical reporter group was easily incorporated into a novel synthetic probe for targeting estrogen receptors in cancer. The efficient complexation conditions are expected to be compatible with 99mTc-radiolabeling to obtain dual function imaging probes.

How to Cite
Hapuarachchige, S.; Bryant, B. K.; Arterburn, J. B. Chem. Heterocycl. Compd. 2014, 50, 254. [Khim. Geterotsikl. Soedin. 2014, 280.]

For this article in the English edition see DOI 10.1007/s10593-014-1469-4


Keywords


chelate; estrogen; hydrazone; tricarbonylrhenium; fluorescence

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