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SYNTHESIS AND ANTIRADICAL PROPERTIES OF 4-ARYL-3,4-DIHYDROQUINOLIN-2-(1H)-ONES, AZA ANALOGS OF NEOFLAVONOIDS

И. Миериня, Α. Стикуте, М. Юре
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Abstract


A convenient one-pot method is proposed for the synthesis of 4-aryl-3,4-dihydroquinolin-2(1H)-ones from the monoanilides of malonic acid and aromatic aldehydes. The antiradical activity of the synthesized 4-aryl-3,4-dihydroquinolin-2(1H)-ones was examined (tests on the inhibition of 2,2-di-phenyl-1-picrylhydrazyl and galvinoxyl). It was found that the highest antiradical activity is exhibited by derivatives of syringaldehyde; the activity of the other compounds is moderate or low, however in the 2,2‑diphenyl-1-picrylhydrazyl inhibition test it is comparable with or higher than for the widely used antioxidant Ionol.

How to Cite
Mieriņa, I.; Stikute, A.; Jure, M. Chem. Heterocycl. Compd. 2014, 50, 1137. [Khim. Geterotsikl. Soedin. 2014, 1232.]

For this article in the English edition see DOI 10.1007/s10593-014-1574-4


Keywords


antioxidant; 4-aryl-3,4-dihydrocarbostyril; 4-aryl-3,4-dihydroquinolin-2(1H)-one; arylidene-malonic acid monoanilide; 4-aryl-2-oxo-1,2,3,4-tetrahydroquinoline; malonic acid monoanilides; antiradical activity; hydroarylation

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