STRUCTURAL ANALOGS OF UMIFENOVIR. 1. SYNTHESIS AND BIOLOGICAL ACTIVITY OF ETHYL 5-HYDROXY-1-METHYL-2-(<i>trans</i>-2-PHENYLCYCLOPROPYL)-1<i>H</i>-INDOLE-3-CARBOXYLATE

Authors

  • Я. Бальзарини Rega Institute for Medical Research
  • Е. А. Ручко Joint-stock Company "Pharm Synthesis"
  • Е. К. Захарова Volgograd State Technical University
  • И. Ю. Каменева Volgograd State Technical University
  • М. Б. Навроцкий Volgograd State Technical University

DOI:

https://doi.org/10.1007/1631

Keywords:

umifenovir, conformationally restricted analogs, antiviral activity

Abstract

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

How to Cite
Balzarini, J.; Ruchko, E. A.; Zakharova, E. K.; Kameneva, I. Yu.; Nawrozkij, M. B. Chem. Heterocycl. Compd. 2014, 50, 489. [Khim. Geterotsikl. Soedin. 2014, 537.]

For this article in the English edition see DOI 10.1007/s10593-014-1499-y

Author Biographies

Я. Бальзарини, Rega Institute for Medical Research

Jan Balzarini

Rega Institute for Medical Research

Minderbroedersstraat, 10, B 3000 Leuven, Belgium

Е. К. Захарова, Volgograd State Technical University

Екатерина Константиновна Захарова

Кафедра "Органическая химия", аспирант кафедры

И. Ю. Каменева, Volgograd State Technical University

Ирина Юрьевна Каменева

Кафедра "Органическая химия", заведующая лабораторией

М. Б. Навроцкий, Volgograd State Technical University

Максим Борисович Навроцкий

Кафедра "Органическая химия", заведующий кафедрой

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Published

2014-05-14

Issue

No. 4 (2014)

Section

Original Papers