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STRUCTURAL ANALOGS OF UMIFENOVIR. 1. SYNTHESIS AND BIOLOGICAL ACTIVITY OF ETHYL 5-HYDROXY-1-METHYL-2-(trans-2-PHENYLCYCLOPROPYL)-1H-INDOLE-3-CARBOXYLATE

Я. Бальзарини, Е. А. Ручко, Е. К. Захарова, И. Ю. Каменева, М. Б. Навроцкий
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Abstract


Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

How to Cite
Balzarini, J.; Ruchko, E. A.; Zakharova, E. K.; Kameneva, I. Yu.; Nawrozkij, M. B. Chem. Heterocycl. Compd. 2014, 50, 489. [Khim. Geterotsikl. Soedin. 2014, 537.]

For this article in the English edition see DOI 10.1007/s10593-014-1499-y


Keywords


umifenovir; conformationally restricted analogs; antiviral activity

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