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THREE-COMPONENT SYNTHESIS OF 4-AROYL-2(1),4,5,7-TETRAHYDROPYRAZOLO[3,4-b]PYRIDIN-6-ONES AND THEIR PROPERTIES

O. N. Petrova, L. L. Zamigajlo, I. M. Gella, V. I. Musatov, S. V. Shishkina, O. V. Shishkin, E. V. Vashchenko, A. V. Borisov, V. V. Lipson
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Abstract


Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4‑aroyl-2(1),4,5,7‑tetrahydro­pyrazolo­[3,4‑b]­pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4‑aroyl-3‑methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.

Keywords


5-aminopyrazoles; arylglyoxals; Meldrum's acid; tetrahydropyrazolo[3,4-b]pyridines; acylation; alkylation; oxidation; reduction; three-component reaction

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