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SYNTHESIS OF 6-ARYL-SUBSTITUTED AZOCINO[5,4-b]INDOLES FROM 1-ARYL-SUBSTITUTED 2-ETHYLTETRAHYDRO-β-CARBOLINES

Л. Г. Воскресенский, Т. Н. Борисова, Т. М. Червякова, А. А. Титов, А. В. Козлов, Е. А. Сорокина, Р. Самавати, А. В. Варламов
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Abstract


We optimized the reaction of tetrahydropyridine ring expansion in 1-aryl-substituted tetrahydro-β‑carbolines by the action of activated alkynes and achieved higher than 70% yields of the target indoloazocines. The substituents in the 1-aryl ring and at the indole nitrogen atom were shown to affect the rate and selectivity of this transformation.

How to Cite
Voskressensky, L. G.; Borisova, T. N.; Chervyakova, T. M.; Titov, A. A.; Kozlov, A. V.; Sorokina, E. A.; Samavati, R.; Varlamov, A. V. Chem. Heterocycl. Compd. 2014, 50, 658. [Khim. Geterotsikl. Soedin. 2014, 716.]

For this article in the English edition see DOI 10.1007/s10593-014-1518-z


Keywords


activated alkynes; azocinoindoles; domino reaction; ring expansion

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