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SYNTHESIS OF PYRIMIDO[2,1-b][1,3,5]THIADIAZINES CONTAINING POLYFLUOROALKYL- AND AMINO ACID FRAGMENTS

О. Г. Худина, А. Е. Иванова, Я. В. Бургарт, В. И. Салоутин
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Abstract


8-Polyfluoroalkylpyrimido[2,1-b][1,3,5]thiadiazine-6-ones containing a structural fragment of amino acid or its ester were synthesized by a multicomponent cyclization of 6-polyfluoroalkyl-2-thiouracils with formaldehyde and amines. The use of diamino acids allowed the preparation of bis(pyrimido-[2,1‑b][1,3,5]thiadiazin-6‑ones), containing an aliphatic linker with a carboxy group. Two of the synthesized compounds exhibited weak antituberculosis activity in vitro.

How to Cite
Khudina, O. G.; Ivanova, A. E.; Burgart, Ya. V.; Saloutin, V. I. Chem. Heterocycl. Compd. 2014, 50, 901. [Khim. Geterotsikl. Soedin. 2014, 976.]

For this article in the English edition see DOI 10.1007/s10593-014-1544-x


Keywords


amino acids; formaldehyde; pyrimido[2,1-b]thiadiazines; 6-polyfluoroalkyl-2-thiouracils; Mannich reaction; tuberculostatic activity

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