Open Access Open Access  Restricted Access Subscription Access

8-ALKYL[1,2,4]TRIAZOLO[5,1-b]PURINES

К. В. Саватеев, Е. Н. Уломский, С. С. Борисов, Е. К. Воинков, В. В. Федотов, В. Л. Русинов
Cover Image

Abstract


A novel method has been developed for the synthesis of 8-alkyl[1,2,4]triazolo[5,1-b]purines from 6‑nitro[1,2,4]triazolo[1,5-a]pyrimidin-7-ones via successive phosphoryl chloride-mediated chloro-desoxygenation, aminodehalogenation, and reduction to give 7-alkylamino-6-amino[1,2,4]triazolo-[1,5‑a]pyrimidines. The latter can be cyclized in the presence of formic acid.

How to Cite
Savateev, K. V.; Ulomsky, E. N.; Borisov, S. S.; Voinkov, E. K.; Fedotov, V. V.; Rusinov, V. L. Chem. Heterocycl. Compd. 2014, 50, 880. [Khim. Geterotsikl. Soedin. 2014, 953.]

For this article in the English edition see DOI 10.1007/s10593-014-1542-z


Keywords


anomalous nucleosides; nitrogen heterocycles; purines; triazolopyrimidines; chlorodes-oxygenation; nitro group reduction

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv