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DIARYL-SUBSTITUTED POLYETHERS WITH ACETOACETANILIDE FRAGMENT IN THE SYNTHESIS OF DIHYDROPYRIMIDINE-CONTAINING PODANDS

Е. С. Радионова, Ю. А. Титова, М. Л. Исенов, О. В. Федорова, Г. Л. Русинов, В. Н. Чарушин
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Abstract


The interaction of ortho-aminoaryl polyethers, derivatives of mono-, di-, and triethylene glycol, with acetyl ketene, generated from 2,2,6-trimethyl-4H-1,3-dioxin-4-one produced acetoacetanilide- containing podands. 2,2,6-Trimethyl-4H-1,3-dioxin-4-one reacted with aminoaryl-substituted podands containing a short polyether chain (1-2 atoms) in toluene medium without catalyst. Acetoacetanilide- containing podands with longer polyether chains could be obtained by using triethylamine or acetic acid as catalyst. Acetoacetanilide-containing podands were used in the Biginelli reaction as СН-active components.

How to Cite
Radionova, E. S.; Titova, Yu. A.; Isenov, M. L.; Fedorova, O. V.; Rusinov, G. L.; Charushin, V. N. Chem. Heterocycl. Compd. 2014, 50, 998. [Khim. Geterotsikl. Soedin. 2014, 1083.]

For this article in the English edition see DOI 10.1007/s10593-014-1555-7


Keywords


acetoacetanilide-containing podands; acetyl ketene; aminoaryl-substituted podands; dihydropyrimidine-containing podands; Biginelli reaction; ultrasonication

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