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MICROWAVE SYNTHESIS OF FUSED 3-THIOCARBAMOYLQUINOLINES BY REINHOUDT REACTION AND THEIR MODIFICATION BY HANTZSCH REACTION

A. Ю. Платонова, А. А. Полуйкова, О. А. Трофимова, Т. В. Глухарева, Ю. Ю. Моржерин
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Abstract


It was shown that the reaction of 2-dialkylaminobenzldehydes with cyanoacetamide proceeds with the formation of Knövenagel condensation products, undergoing cyclization through the tert-amino effect, and can be significantly accelerated in a microwave reactor. The synthesized tetrahydroquinoline-3-carbothioamides react with α-bromoacetophenone in microwave reactor producing 3-(1,3-thiazol-2-yl)tetrahydroquinolines.

How to Cite
Platonova, A. Yu.; Poluikova, A. A.; Trofimova, O. A.; Glukhareva, T. V.; Morzherin, Yu. Yu. Chem. Heterocycl. Compd. 2015, 50, 1450. [Khim. Geterotsikl. Soedin. 2014, 1576.]

For this article in the English edition see DOI 10.1007/s10593-014-1609-x


Keywords


Knövenagel condensation; Reinhoudt reaction; Hantsch reaction; tert-amino effect; quinolines; thioamides; thiazoles; microwave irradiation

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