1,2,3-THIADIAZOLYL ISOCYANATES IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS. STUDY OF THE CYTOTOXIC ACTIVITY OF N-(4-METHYL-1,2,3-THIADIAZOLYL-5-YL)-N'-(4-METHYLPHENYL)UREA

Abstract

A simple method is proposed for the synthesis of 1,2,3-thiadiazolylureas by the reaction of 1,2,3-thiadiazolyl isocyanates with primary amines. 1,2,3-Thiadiazolyl isocyanates were obtained in situ by the Curtius rearrangement of 1,2,3-thiadiazolylcarbonyl azides. Cytokinin activity was tested for N‑(4‑methyl-1,2,3-thiadiazol-5-yl)-N'-(4-methylphenyl)urea, which is an analog of thidiazuron, differing in the presence of two methyl groups in the molecule.

How to Cite
Kalinina, T. A.; Shakhmina, Yu. S.; Glukhareva, T. V.; Morzherin, Yu. Yu.; Fan, Z.-J.; Borzenkova, R. A.; Skolobanova, E. S.; Kiseleva, I. S. Chem. Heterocycl. Compd. 2014, 50, 1039. [Khim. Geterotsikl. Soedin. 2014, 1127.]

For this article in the English edition see DOI 10.1007/s10593-014-1561-9