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QUINOXALINE-BASED INHIBITORS OF MALARIAL PROTEASE PfSUB1

S. S. Kher, M. Penzo, S. Fulle, J. P. Ebejer, P. W. Finn, M. J. Blackman, A. Jirgensons
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Abstract


2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analogs series and investigation of their inhibitory activity provided preliminary structure–activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.

How to Cite
Kher, S. S.; Penzo, M.; Fulle, S.; Ebejer, J. P.; Finn, P. W.; Blackman, M. J.; Jirgensons, A. Chem. Heterocycl. Compd. 2015, 50, 1457. [Khim. Geterotsikl. Soedin. 2014, 1583.]

For this article in the English edition see DOI 10.1007/s10593-014-1610-4


Keywords


quinoxaline; inhibitors; malaria; Malaria Box; PfSUB1 protease

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