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INTERACTION OF 3,8-DISUBSTITUTED IMIDAZO[5,1-c][1,2,4]TRIAZINES WITH NUCLEOPHILES

Е. В. Садчикова, В. С. Мокрушин
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Abstract


We studied the reactivity of diethyl 4-aminoimidazo[5,1-с][1,2,4]triazine-3,8-dicarboxylate in reactions with nucleophiles and demonstrated the possibility of selective formation of monoamides by interaction with primary and secondary aliphatic amines. It was determined that the carbon atom at position 4 of imidazo[1,5-с][1,2,4]triazine system underwent nucleophilic attack, enabling the synthesis of imidazo-[1',5':3,4][1,2,4]triazino[5,6-b][1,5]benzoxazepines and imidazo[1',5':3,4][1,2,4]triazino[5,6‑b][1,5]benzodiazepines, as well as (pyrazol-4-ylidenehydrazino)imidazoles, depending on the bisnucleophile used.

How to Cite
Sadchikova, E. V.; Mokrushin, V. S. Chem. Heterocycl. Compd. 2014, 50, 1014. [Khim. Geterotsikl. Soedin. 2014, 1100.]

For this article in the English edition see DOI 10.1007/s10593-014-1557-5


Keywords


diazepines; imidazolylhydrazones; imidazotriazines; oxazepines; polycondensed heterocyclic systems

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