FACILE AND RAPID SYNTHESIS OF 5-SUBSTITUTED 1<i>H</i>-TETRAZOLES <i>via</i> A MULTICOMPONENT DOMINO REACTION USING NICKEL(II) OXIDE NANOPARTICLES AS CATALYST

Abstract

2-(1H-Tetrazol-5-yl)acrylonitrile derivatives were synthesized through multicomponent domino Knoevenagel condensation/1,3-dipolar cycloaddition reaction of carbonyl compounds, malononitrile, and sodium azide in the presence of NiO nanoparticles as a highly efficient catalyst. This method has the advantage of very short reaction times, high yields, simple methodology, and easy work-up. The catalyst can be recovered and reused while maintaining good yields.

How to Cite
Safaei-Ghomi, J.; Paymard-Samani, S. Chem. Heterocycl. Compd. 2015, 50, 1567. [Khim. Geterotsikl. Soedin. 2014, 1706.]

For this article in the English edition see DOI 10.1007/s10593-014-1625-x