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FACILE AND RAPID SYNTHESIS OF 5-SUBSTITUTED 1H-TETRAZOLES via A MULTICOMPONENT DOMINO REACTION USING NICKEL(II) OXIDE NANOPARTICLES AS CATALYST

J. Safaei-Ghomi, S. Paymard-Samani
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Abstract


2-(1H-Tetrazol-5-yl)acrylonitrile derivatives were synthesized through multicomponent domino Knoevenagel condensation/1,3-dipolar cycloaddition reaction of carbonyl compounds, malononitrile, and sodium azide in the presence of NiO nanoparticles as a highly efficient catalyst. This method has the advantage of very short reaction times, high yields, simple methodology, and easy work-up. The catalyst can be recovered and reused while maintaining good yields.

How to Cite
Safaei-Ghomi, J.; Paymard-Samani,S. Chem. Heterocycl. Compd. 2015, 50, 1567. [Khim. Geterotsikl. Soedin. 2014, 1706.]

For this article in the English edition see DOI 10.1007/s10593-014-1625-x


Keywords


NiO nanoparticles; 2-(1H-tetrazol-5-yl)acrylonitrile; 1,3-dipolar cycloaddition; Knoevenagel condensation

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