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EFFICIENT SYNTHESIS, ANTIOXIDANT AND ANTIMICROBIAL PROFILES OF 2-(ARYLAMINO)- AND 2-(HETEROARYLAMINO)-1,3,4,2λ5-DIOXAZAPHOSPHININ-2-ONES

K. Uma Maheswara Rao, S. Santhi Sudha, B. Satheesh Krishna, P. Ramamohan, C. Suresh Reddy
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Abstract


Synthesis of 5,6-diphenyl-6H-1,3,4,2λ5-dioxazaphosphinin-2-ones having an amino substituent at phosphorus atom has been accomplished in two steps. It involves the preparation of 2-chloro intermediate and its subsequent reaction with various aromatic or heterocyclic amines in dry tetrahydrofuran and triethylamine at reflux temperature. These compounds were characterized by IR, 1H,13C, 31P NMR spectroscopy and mass spectrometry, and elemental analysis. All the title compounds were screened for antioxidant properties by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay, reducing power assay, and lipid peroxidation assay. The tested compounds exhibited potent dose-dependent in vitro antioxidant activity, as well as a significant antimicrobial activity.

How to Cite
Uma Maheswara Rao, K.; Santhi Sudha, S.; Satheesh Krishna, B.; Ramamohan, P.; Suresh Reddy, C. Chem. Heterocycl. Compd. 2015, 51, 194. [Khim. Geterotsikl. Soedin. 2015, 51, 194.]

For this article in the English edition see DOI 10.1007/s10593-015-1680-y


Keywords


6H-1,3,4,2λ5-dioxazaphosphinin-2-ones; phosphoryl chloride; antimicrobial activity; antioxidant activity

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