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SYNTHESIS, CHARACTERIZATION, AND ANTIMICROBIAL ACTIVITY OF BENZIMIDAZOLE-DERIVED CHALCONES CONTAINING 1,3,4-OXADIAZOLE MOIETY

Gangadhar A. Meshram, Vipul A. Vala
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Abstract


A series of novel benzimidazole-derived chalcones containing the 1,3,4-oxadiazole moiety were synthesized and characterized by IR, 1H, 13C NMR, and mass spectra and elemental analysis. The synthesized compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against three fungal species. Antibacterial activity revealed that tested compounds exhibited potent activity whereas some compounds exhibited moderate antifungal activity as compared to the standards.

How to Cite
Meshram, G. A.; Vala, V. A. Chem. Heterocycl. Compd. 2015, 51, 44. [Khim. Geterotsikl. Soedin. 2015, 51, 44.]

For this article in the English edition see DOI 10.1007/s10593-015-1653-1


Keywords


benzimidazole; chalcone; 1,3,4-oxadiazole; antibacterial activity; antifungal activity

Full Text: PDF Supplementary File(s): Supporting information (2MB)


 

 

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