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AN EFFICIENT SOLVENTLESS SYNTHESIS OF CYCLOALKENO-1,2,3-SELENADIAZOLES, THEIR ANTIMICROBIAL STUDIES, AND COMPARISON WITH PARENT SEMICARBAZONES

Aditi A. Jadhav, Vaishali P. Dhanwe, Prasad G. Joshi, Pawan Kumar Khanna
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Abstract


A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent  semicarbazones were screened for their antimicrobial activity
against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli, S. aureus, S. typhi, and P. aeruginosa. Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa. It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.

How to Cite
Jadhav, A. A.; Dhanwe, V. P.; Joshi, P. G.; Khanna, Pawan K. Chem. Heterocycl. Compd. 2015, 51, 102. [Khim. Geterotsikl. Soedin. 2015, 51, 102.]

For this article in the English edition see DOI 10.1007/s10593-015-1666-9

 


Keywords


organoselenium compounds; selenadiazoles; semicarbazones; grinding; solventless synthesis

Full Text: PDF Supplementary File(s): Supporting information (302KB)


 

 

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