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Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1H)-one and 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids

Aндрей В. Диденко, Mихаил В. Воробьев, Дмитрий В. Севенард, Вячеслав Я. Сосновских
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Abstract


Starting from 3-(trifluoromethyl)quinoxalin-2(1H)-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, α-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3(Tri(di)fluoromethyl)quinoxaline-2-carboxylic acids were obtained for the first time and used for the synthesis of 2-amino-3-(tri(di)fluoromethyl)quinoxalines and 2-(2-aminothiazol-4-yl)-3-(trifluoromethyl)quinoxaline.

How to Cite
Didenko, A. V.; Vorobiev, M. V.; Sevenard, D. V.; Sosnovskikh, V. Ya. Chem. Heterocycl. Compd. 2015, 51, 259. [Khim. Geterotsikl. Soedin. 2015, 51, 259.]

For this article in the English edition see DOI 10.1007/s10593-015-1694-5

 


Keywords


quinoxaline-2-carboxylic acid; quinoxaline-2(1H)-thione; quinoxalin-2(1H)-one; 2-substituted 3-(tri(di)fluoromethyl)quinoxalines

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