4-HYDROXYQUINOL-2-ONES. 195. SYNTHESIS OF NOVEL, POTENTIAL ANALGESICS BASED ON 4-(HETARYLMETHYL)AMINO-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS

Authors

  • И. В. Украинец National University of Pharmacy
  • Е. В. Моспанова Chemical Technology Institute, V. Dal East-Ukrainian National University
  • Л. В. Савченкова Lugansk State Medical University
  • С. И. Янкович Lugansk State Medical University

DOI:

https://doi.org/10.1007/2177

Keywords:

4-N-R-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, analgesic activity, bioisosteric replacement

Abstract

From the viewpoint of the method of bioisosteric replacement we have carried out the synthesis of a series of 4-(hetarylmethyl)amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. For several examples it has been shown experimentally that the aromatic ring in the benzyl fragment of 4-benzylamino-2-oxo-1,2‑dihydroquinoline-3-carboxylic acid can be replaced by an isosteric heterocycle without lowering the analgesic properties.

How to Cite
Ukrainets, I. V.; Mospanova, E. V.; Savchenkova, L. V.; Yankovich, S. I. Chem. Heterocycl. Compd. 2011, 47(1), 67. [Khim. Geterotsikl. Soedin. 2011, 90.]

For this article in the English edition see DOI 10.1007/s10593-011-0721-4

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Published

2014-12-18

Issue

No. 1 (2011)

Section

Original Papers