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MICROWAVE-ASSISTED SYNTHESIS OF SOME NEW COUMARIN DERIVATIVES INCLUDING 1,2,4-TRIAZOL-3-ONE AND INVESTIGATION OF THEIR BIOLOGICAL ACTIVITIES

Bahittin Kahveci, Fatih Yılmaz, Emre Menteşe, Serdar Ülker
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Abstract


By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy workup and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.

How to Cite
Kahveci, B.; Yılmaz, F.; Menteşe, E.; Ülker, S. Chem. Heterocycl. Compd. 2015, 51, 447. [Khim. Geterotsikl. Soedin. 2015, 51, 447.]

For this article in the English edition see DOI 10.1007/s10593-015-1714-5


Keywords


benzotriazole; coumarin; 1,2,4-triazol-3-one; antimicrobial activity; catalyst-free reaction; lipase inhibition; microwave irradiation

Full Text: PDF (Russian) Supplementary File(s): Supporting info (2MB)


 

 

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