NUCLEOPHILIC SUBSTITUTION OF NITRO GROUP IN NITROTRIAZOLO- TRIAZINES AS A MODEL OF POTENTIAL INTERACTION WITH CYSTEINE-CONTAINING PROTEINS

Authors

  • Владимир Л. Русинов Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia
  • Ирина М. Сапожникова Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia
  • Евгений Н. Уломский Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia
  • Наталья Р. Медведева Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia
  • Владимир В. Егоров Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia
  • Олег И. Киселев Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia
  • Элла Г. Деева Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia
  • Андрей В. Васин Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia
  • Олег Н. Чупахин Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi St. / 20 Akademicheskaya St., Yekaterinburg 620990, Russia

DOI:

https://doi.org/10.1007/2244

Keywords:

azolo[5, 1-с]triazines, cysteine, glutathione, nitro compounds, Triazavirin, metabolic transformations, , nucleophilic substitution

Abstract

The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives.

How to Cite
Rusinov, V. L.; Sapozhnikova, I. M.; Ulomskii, E. N.; Medvedeva, N. R.; Egorov, V. V.; Kiselev, O. I.; Deeva, E. G.; Vasin, A. V.; Chupakhin, O. N. Chem. Heterocycl. Compd. 2015, 51, 275. [Khim. Geterotsikl. Soedin. 2015, 51, 275.]

For this article in the English edition see DOI 10.1007/s10593-015-1695-4

Author Biographies

Владимир Л. Русинов, Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia

Владимир Леонидович Русинов

Ирина М. Сапожникова, Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia

Ирина Михайловна Сапожникова

Кафедра органической химии, аспирант, младший научный сотрудник

Евгений Н. Уломский, Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia

Евгений Нарциссович Уломский

Наталья Р. Медведева, Ural Federal University named after the First President of Russia Boris Yeltsin, 19 Mira St.,Yekaterinburg 620002, Russia

Наталья Розыевна Медведева

Владимир В. Егоров, Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia

Владимир Валерьевич Егоров

Олег И. Киселев, Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia

Олег Иванович Киселев

Элла Г. Деева, Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia

Элла Германовна Деева

Андрей В. Васин, Research Institute of Influenza, Minisrty of Healthcare of the Russian Federation, 15/17 Prof. Popov St., Saint-Petersburg 197376, Russia

Андрей Владимирович Васин

Олег Н. Чупахин, Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi St. / 20 Akademicheskaya St., Yekaterinburg 620990, Russia

Олег Николаевич Чупахин

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Published

2015-03-18

Issue

Vol. 51 No. 3 (2015)

Section

Original Papers