Open Access Open Access  Restricted Access Subscription Access

NUCLEOPHILIC SUBSTITUTION OF NITRO GROUP IN NITROTRIAZOLO- TRIAZINES AS A MODEL OF POTENTIAL INTERACTION WITH CYSTEINE-CONTAINING PROTEINS

Владимир Л. Русинов, Ирина М. Сапожникова, Евгений Н. Уломский, Наталья Р. Медведева, Владимир В. Егоров, Олег И. Киселев, Элла Г. Деева, Андрей В. Васин, Олег Н. Чупахин
Cover Image

Abstract


The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives.

How to Cite
Rusinov, V. L.; Sapozhnikova, I. M.; Ulomskii, E. N.; Medvedeva, N. R.; Egorov, V. V.; Kiselev, O. I.; Deeva, E. G.; Vasin, A. V.; Chupakhin, O. N. Chem. Heterocycl. Compd. 2015, 51, 275. [Khim. Geterotsikl. Soedin. 2015, 51, 275.]

For this article in the English edition see DOI 10.1007/s10593-015-1695-4


Keywords


azolo[5,1-с]triazines; cysteine; glutathione; nitro compounds; Triazavirin; metabolic transformations,; nucleophilic substitution

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv