RECYCLIZATION OF BENZOFUROPYRIDINES BY THE ACTION OF ACTIVATED ALKYNES IN THE SYNTHESIS OF SPIRO[BENZOFUROPYRIDINES], REPRESENTATIVES OF A NEW CLASS OF ACETYLCHOLINESTERASE INHIBITORS

Authors

  • Л. Г. Воскресенский Peoples' Friendship University of Russia
  • C. А. Ковалева Peoples' Friendship University of Russia
  • Т. Н. Борисова Peoples' Friendship University of Russia
  • А. Б. Ересько L. M. Litvinenko Institute of Physical Organic and Coal Chemistry
  • В. С. Толкунов L. M. Litvinenko Institute of Physical Organic and Coal Chemistry
  • С. В. Толкунов L. M. Litvinenko Institute of Physical Organic and Coal Chemistry
  • А. В. Листратова Peoples' Friendship University of Russia
  • М. Де Кандиа Università degli Studi di Bari
  • К. Алтомаре Università degli Studi di Bari
  • А. В. Варламов Peoples' Friendship University of Russia

DOI:

https://doi.org/10.1007/226

Keywords:

activated alkynes, tetrahydrobenzofuropyridines, acetylcholinesterase inhibition, domino reactions, ring expansion

Abstract

A study was carried out on the domino transformations of tetrahydrobenzofuro[2,3-c]pyridines and tetrahydrobenzofuro[3,2-c]pyridines by the action of activated alkynes in methanol and acetonitrile. This reaction is a new method for the synthesis of spiro[benzofuropyridines] showing acetylcholinesterase inhibition activity.

Authors: L. G. Voskressensky, S. A. Kovaleva, T. N. Borisova, A. B. Eresko, V. S. Tolkunov, S. V. Tolkunov, A. V. Listratova, M. de Candia, C. Altomare, and A. V. Varlamov.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (6), pp 930-940

http://link.springer.com/article/10.1007/s10593-013-1328-8

Author Biographies

М. Де Кандиа, Università degli Studi di Bari

M. De Candia

К. Алтомаре, Università degli Studi di Bari

C. Altomare

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Published

2013-03-19

Issue

No. 6 (2013)

Section

Original Papers