Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS AND POTENT CYTOTOXICITY OF SOME NOVEL IMIDAZOPYRIDINE DERIVATIVES AGAINST MCF-7 HUMAN BREAST ADENOCARCINOMA CELL LINE

Mustafa Orhan Püsküllü, Cigdem Karaaslan, Filiz Bakar, Hakan Goker
Cover Image

Abstract


A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 μM, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.

How to Cite
Püsküllü, M. O.; Karaaslan, C.; Bakar, F.; Göker, H. Chem. Heterocycl. Compd. 2015, 51, 723. [Khim. Geterotsikl. Soedin. 2015, 51, 723.]

For this article in the English edition see DOI 10.1007/s10593-015-1765-7


Keywords


carboxamidine; 3H-imidazo[4,5-b]pyridine; 3H-imidazo[4,5-c]pyridine; MCF-7 cell line; cytotoxicity; steric hindrance

Full Text: PDF Supplementary File(s): Supporting information (4MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv