A FACILE SYNTHESIS OF <i>N</i>-SUBSTITUTED 2,5-DIMETHYLPYRROLES WITH SACCHARIN AS A GREEN CATALYST

Authors

  • Namratha Bhandari Dept. of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, India-576104
  • Santosh L Gaonkar Dept. of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, India-576104

DOI:

https://doi.org/10.1007/2313

Keywords:

pyrrole, saccharin, cyclocondensation, Paal–Knorr reaction

Abstract

The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal–Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.

How to Cite
Bhandari, N.; Gaonkar, S. L. Chem. Heterocycl. Compd. 2015, 51, 320. [Khim. Geterotsikl. Soedin. 2015, 51, 320.]

For this article in the English edition see DOI 10.1007/s10593-015-1701-x

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Published

2015-04-22

Issue

Vol. 51 No. 4 (2015)

Section

Original Papers