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A FACILE SYNTHESIS OF N-SUBSTITUTED 2,5-DIMETHYLPYRROLES WITH SACCHARIN AS A GREEN CATALYST

Namratha Bhandari, Santosh L Gaonkar
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Abstract


The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal–Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.

How to Cite
Bhandari, N.; Gaonkar, S. L. Chem. Heterocycl. Compd. 2015, 51, 320. [Khim. Geterotsikl. Soedin. 2015, 51, 320.]

For this article in the English edition see DOI 10.1007/s10593-015-1701-x


Keywords


pyrrole; saccharin; cyclocondensation; Paal–Knorr reaction

Full Text: PDF Supplementary File(s): Supplementary materials (803KB)


 

 

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