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AN EFFICIENT SYNTHESIS OF 1,3,7-TRIAZASPIRO[4.4]NONANE-2,4-DIONE DERIVATIVES AND ANTIMICROBIAL ACTIVITY THEREOF

Константин Ю. Кроленко, Алексей В. Силин, Сергей В. Власов, Ирина А. Журавель, Сергей Н. Коваленко
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Abstract


Efficient methods for the synthesis of 1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives possessing an unsaturated pyrrolidine cycle have been developed affording intermediates and target compounds in high yields not requiring additional purification. Antimicrobial activity of the synthesized compounds was studied.

How to Cite
Krolenko, K. Yu.; Silin, O. V.; Vlasov, S. V.; Zhuravel, I. O.; Kovalenko, S. M. Chem. Heterocycl. Compd. 2015, 51, 472. [Khim. Geterotsikl. Soedin. 2015, 51, 472.]

For this article in the English edition see DOI 10.1007/s10593-015-1721-6

 

 


Keywords


hydantoin; pyrrolidine ring; alkylation; antimicrobial activity

Full Text: PDF (Russian) Supplementary File(s): Supplementary materials (3MB)


 

 

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