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MICROWAVE-ASSISTED SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRAZOLINES

Ashok Dongamanti, Mohan Gandhi Devulapally, Vikas Kumar Aamate, Srinivas Gundu
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Abstract


A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.

How to Cite
Dongamanti, A.; Devulapally, M. G.; Aamate, V. K.; Gundu, S. Chem. Heterocycl. Compd. 2015, 51, 872. [Khim. Geterotsikl. Soedin. 2015, 51, 872.]

For this article in the English edition see DOI 10.1007/s10593-015-1790-6


Keywords


antimicrobial activity; chalcones; Michael addition; microwave irradiation; pyrazolines

Full Text: PDF Supplementary File(s): Supporting information (5MB)


 

 

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