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A novel method for the domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles and studies of stereochemical characteristics of formation and structure thereof

Михаил Ю. Иевлев, Олег В. Ершов, Ангелина Г. Миловидова, Михаил Ю. Беликов, Олег Е. Насакин
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Abstract


A novel universal method for the preparative synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles was developed, previously unknown 1- and 8-aryl-substituted derivatives were synthesized, stereochemical characteristics of this transformation were studied, and the reasons for its diastereoselectivity were identified.

How to Cite
Ievlev, M. Yu.; Ershov, O. V.; Milovidova, A. G.; Belikov, M. Yu.; Nasakin, O. E. Chem. Heterocycl. Compd. 2015, 51, 457. [Khim. Geterotsikl. Soedin. 2015, 51, 457.]

For this article in the English edition see DOI 10.1007/s10593-015-1720-7


Keywords


2,7-dioxabicyclo[3.2.1]octane; 4-oxoalkane-1,1,2,2-tetracarbonitriles; cytotoxicity; diastereoselectivity; domino reactions; iminolactone ring

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