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ENANTIOSELECTIVE FORMAL SYNTHESIS OF DOXAPRAM

Andrejs Krasikovs
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Abstract


The use of LiHMDS with equimolar amount of sparteine in toluene results in the formation of enantiomerically enriched γ-lactam – a useful synthon for the synthesis of (R)-(+)-doxapram.

How to Cite
Krasikovs, A. Chem. Heterocycl. Compd. 2015, 51, 385. [Khim. Geterotsikl. Soedin. 2015, 51, 385.]

For this article in the English edition see DOI 10.1007/s10593-015-1712-7


Keywords


doxapram; lactam; intramolecular alkylation; stereoselective synthesis

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