ENANTIOSELECTIVE FORMAL SYNTHESIS OF DOXAPRAM

Authors

  • Andrejs Krasikovs Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006

DOI:

https://doi.org/10.1007/2373

Keywords:

doxapram, lactam, intramolecular alkylation, stereoselective synthesis

Abstract

The use of LiHMDS with equimolar amount of sparteine in toluene results in the formation of enantiomerically enriched γ-lactam – a useful synthon for the synthesis of (R)-(+)-doxapram.

How to Cite
Krasikovs, A. Chem. Heterocycl. Compd. 2015, 51, 385. [Khim. Geterotsikl. Soedin. 2015, 51, 385.]

For this article in the English edition see DOI 10.1007/s10593-015-1712-7

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Published

2015-04-23

Issue

Vol. 51 No. 4 (2015)

Section

Letters to the Editor