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SYNTHESIS OF SPIRO DERIVATIVES OF 1,2,3-TRIAZOLO[5,1-b][1,3,4]THIADIAZINES AND BIOLOGICAL ACTIVITY THEREOF

Татьяна А. Калинина, Ольга A. Быстрых, Варвара А. Поздина, Татьяна В. Глухарева, Мария B. Улитко, Юрий Ю. Моржерин
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Abstract


3-Cyclopentylidene(cyclohexylidene)amino-3H-1,2,3-triazole-4-thiolates, formed via Dimroth rearrangement of 1,2,3-thiadiazolylhydrazones of cyclopentanone and cyclohexanone in the presence of triethylamine, reacted in situ with α-bromoacetophenones with the formation of spirocyclic 6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazines. The effect of the obtained compounds on the viability and proliferative activity of four lines of cell cultures was studied. The selective proliferative activity was determined.

How to Cite
Kalinina, T. A.; Bystrykh, O. A.; Pozdina, V. A.; Glukhareva, T. V.; Ulitko, M. V.; Morzherin, Yu. Yu. Chem. Heterocycl. Compd. 2015, 51, 589. [Khim. Geterotsikl. Soedin. 2015, 51, 589.]

For this article in the English edition see DOI 10.1007/s10593-015-1742-1

 

 


Keywords


spirocyclic compounds; 1,3,4-thiadiazines; 1,2,3-triazoles; continuous cell lines; cytotoxicity; dermal fibroblasts; Dimroth rearrangement; МТТ assay; proliferation

Full Text: PDF (Russian) Supplementary File(s): Supporting information (5MB)


 

 

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