IN A SEARCH FOR SELECTIVE INHIBITORS OF CARBONIC ANHYDRASES: COUMARIN AND ITS BIOISOSTERES – SYNTHESIS AND DERIVATIZATION

Authors

  • Raivis Žalubovskis Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/2455

Keywords:

carbonic anhydrases, coumarin, dithiocoumarin, sulfocoumarin, thiocoumarin, thioxocoumarin

Abstract

This review describes the preparation and derivatization of coumarin and its bioisosteres – thioxocoumarin, thiocoumarin, dithiocoumarin, and sulfocoumarin derivatives triggered by natural product and utilized in the investigation of inhibitors of carbonic anhydrases with a focus on cancer-associated isoforms of carbonic anhydrases.

How to Cite
Žalubovskis, R. Chem. Heterocycl. Compd. 2015, 51, 607. [Khim. Geterotsikl. Soedin. 2015, 51, 607.]

For this article in the English edition see DOI 10.1007/s10593-015-1748-8

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Published

2015-07-31

Issue

Vol. 51 No. 7 (2015)

Section

Review Articles