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IN A SEARCH FOR SELECTIVE INHIBITORS OF CARBONIC ANHYDRASES: COUMARIN AND ITS BIOISOSTERES – SYNTHESIS AND DERIVATIZATION

Raivis Žalubovskis
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Abstract


This review describes the preparation and derivatization of coumarin and its bioisosteres – thioxocoumarin, thiocoumarin, dithiocoumarin, and sulfocoumarin derivatives triggered by natural product and utilized in the investigation of inhibitors of carbonic anhydrases with a focus on cancer-associated isoforms of carbonic anhydrases.

How to Cite
Žalubovskis, R. Chem. Heterocycl. Compd. 2015, 51, 607. [Khim. Geterotsikl. Soedin. 2015, 51, 607.]

For this article in the English edition see DOI 10.1007/s10593-015-1748-8


Keywords


carbonic anhydrases; coumarin; dithiocoumarin; sulfocoumarin; thiocoumarin; thioxocoumarin

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