FORMATION OF MAGNETOLIPOSOMES USING SELF-ASSEMBLING 1,4-DIHYDROPYRIDINE DERIVATIVE AND MAGHEMITE γ-Fe<sub>2</sub>O<sub>3</sub> NANOPARTICLES

Authors

  • Oksana Petrichenko Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006 University of Latvia, 8 Zellu St., Riga LV-1002, Latvia
  • Aiva Plotniece Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006
  • Karlis Pajuste Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Velta Ose Latvian Biomedical Research and Study Centre, Ratsupites St., Riga LV-1067
  • Andrejs Cēbers University of Latvia, 8 Zellu St., Riga LV-1002

DOI:

https://doi.org/10.1007/2457

Keywords:

cationic 1, 4-dihydropyridine, ferrofluid, magnetoliposomes, reverse-phase evaporation method, spontaneous swelling method

Abstract

This work demonstrates studies of ferromagnetic nanoparticle functionalization by a lipid-like compound, cationic pyridine amphiphile derived from 1,4-dihydropyridine, 1,1'-{[3,5-bis(dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]dimethanediyl}dipyridinium dibromide, and determination of optimal conditions for the production of magnetoliposomes. The following methodologies, such as sonication, spontaneous swelling, and reverse-phase evaporation, were used for the preparation of liposomes. Ferrofluid containing γ-Fe2O3 nanoparticles with a positively charged surface was used for the preparation of magnetoliposomes. The obtained soft matter objects were studied by optical microscopy, transmission electron microscopy, and dynamic light scattering techniques. The optimal conditions for the production of magnetoliposomes were found by spontaneous swelling and reverse-phase evaporation methods using ferrofluid with positively charged γ-Fe2O3 nanoparticles and cationic 1,4-dihydropyridine derivative.

How to Cite
Petrichenko, O.; Plotniece, A.; Pajuste, K.; Ose, V.; Cēbers, A. Chem. Heterocycl. Compd. 2015, 51, 672. [Khim. Geterotsikl. Soedin. 2015, 51, 672.]

For this article in the English edition see DOI 10.1007/s10593-015-1755-9

Author Biographies

Oksana Petrichenko, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006 University of Latvia, 8 Zellu St., Riga LV-1002, Latvia

Oksana Petrichenko

Aiva Plotniece, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006

Aiva Plotniece

Karlis Pajuste, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

Karlis Pajuste

Velta Ose, Latvian Biomedical Research and Study Centre, Ratsupites St., Riga LV-1067

Velta Ose

Andrejs Cēbers, University of Latvia, 8 Zellu St., Riga LV-1002

Andrejs Cēbers

Published

2015-07-31

Issue

Section

Original Papers