SYNTHESIS OF 2,5-BIS(2-AMINOTHIAZOL-5-YL)-3,6-DICHLORO-1,4-BENZOQUINONES

Abstract

A series of 2-(2-aminothiazol-5-yl)-3,6-dichloro-5-diethylaminoethenyl-1,4-benzoquinones was synthesized from 2-(2-aminothiazol-5-yl)-3,5,6-trichloro-1,4-benzoquinones using acetaldehyde and diethylamine in toluene solution. Refluxing these compounds with substituted thioureas in acetonitrile in the presence of hydrochloric acid gives the corresponding 2,5-bis(2-aminothiazol-5-yl)-3,6-dichlorohydroquinones which can be oxidized to the target products with ferric chloride in aqueous DMF.

Authors: N. G. Batenko, R. Valters, and G. Karlivans.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (6), pp 733-737

http://link.springer.com/article/10.1007/BF02297684