SYNTHESIS OF PYRAZOLO[1,5-<i>a</i>]-PYRIMIDINES BY REACTION OF 3,5-DIAMINO-4-NITROPYRAZOLE WITH ACETOACETIC ESTER IN THE PRESENCE OF ALKALINE AGENTS

Authors

  • B. А. Mакаров State Science Center of the Russian Federation NIOPIK (Scientific Research Institute of Organic Intermediates and Dyes), Moscow
  • Н. П. Соловьева State Science Center of the Russian Federation NIOPIK (Scientific Research Institute of Organic Intermediates and Dyes), Moscow
  • O. Б. Рябова State Science Center of the Russian Federation NIOPIK (Scientific Research Institute of Organic Intermediates and Dyes), Moscow
  • В. Г. Граник State Science Center of the Russian Federation NIOPIK (Scientific Research Institute of Organic Intermediates and Dyes), Moscow

DOI:

https://doi.org/10.1007/25

Keywords:

nitropyrazole, acetoacetic ester, pyrazolopyrimidine, diketene

Abstract

Two major compounds are formed in the reaction of 3,5-diamino-4-nitropyrazole with acetoacetic ester: 2‑amino-5-methyl-3-nitro-4,7-dihydropyrazolo[1,5-a]pyrimidin-7-one and 3-amino-5-(b-hydroxy-crotonyl)amino-4-nitropyrazole. The latter is converted to bicyclic dihydropyrazolo[1,5-a]-pyrimidinone in solutions with heating.

Authors: V. A. Makarov, N. P. Solov'eva, O. B. Ryabova, and V. G. Granik.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (1), pp 65-69

http://link.springer.com/article/10.1007/BF02256847

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Published

2012-09-28

Issue

No. 1 (2000)

Section

Original Papers